Trypsin Chymotrypsin

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Tissue damage of all types, such as surgical or accidental injuries, fractures, and burns, stimulates a well-orchestrated, physiological process of healing, which ultimately leads to structural and functional restoration of the damaged tissues.

 Trypsin:chymotrypsin is an oral proteolytic enzyme preparation which has been in clinical use since the 1960s. It provides better resolution of inflammatory symptoms and promotes speedier recovery of acute tissue injury than several of the other existing enzyme preparations. This review article revisits the role and clinical utility of trypsin:chymotrypsin combination in tissue repair.

Role of Trypsin,Chymotrypsin in Tissue Repair

Trypsin,chymotrypsin is a widely used oral proteolytic enzyme combination to hasten repair of traumatic, surgical, and orthopedic injuries. It shows high bioavailability without losing its biological activities as an anti-inflammatory, anti-edematous, fibrinolytic, antioxidant, and anti-infective agent. These properties help in resolving signs and symptoms of inflammation due to tissue injury and facilitate the repair process. It also demonstrates analgesic effects and reduces the pain associated with healing.

Beneficial Effects of Trypsin,Chymotrypsin in Tissue Repair

Despite extensive evaluation, the mechanisms of beneficial effects associated with trypsin,chymotrypsin combination remain incompletely understood . The postulated mechanisms are briefly discussed below.
Another mechanism which contributes to improved healing with trypsin,chymotrypsin combination is that it helps in maintaining high levels of α1-antitrypsin for a long duration. Consequently, the activity of proteolytic enzymes and their degradative effects are countered, leading to reduction in inflammatory milieu, ROS and oxidative stress, and faster healing. Additionally, the enzyme preparation also increases enzymatic and non-enzymatic antioxidant levels, which further augments its antioxidant and anti-inflammatory efficacy . The anti-infective property of the enzyme complex may be explained by enhanced phagocytic activity of natural killer cells and macrophages due to trypsin . It is also interesting to note that the combination has been shown to reduce the constant loss of albumin and pre-albumin after surgical procedures. Consequently, it may prevent many of the life-threatening postoperative complications, such as shock . Overall, the use of trypsin,chymotrypsin in patients with acute injury reduces inflammatory edema and tissue destruction, which in turn facilitates rapid healing .  provides a comprehensive overview of postulated mechanisms of beneficial effects of trypsin,chymotrypsin in tissue repair .

Efficacy and Safety of Trypsin,Chymotrypsin in Various Clinical Indications

Numerous clinical trials have attested the efficacy and safety of trypsin,chymotrypsin combination in resolving inflammation and edema secondary to tissue damage of different types, such as accidental injuries, surgical and orthopedic injuries, burns, and sciatica 

Owing to anti-inflammatory, anti-edematous, fibrinolytic, anti-infective, and analgesic effects, trypsin,chymotrypsin oral combination has emerged as a promising treatment to facilitate healing of traumatic injuries. It promotes speedier recovery and better resolution of inflammatory signs and symptoms due to tissue injury than several of the other existing enzyme preparations. It also demonstrates analgesic effects and reduces pain associated with healing. The efficacy and safety of trypsin,chymotrypsin in accidental injuries, surgical and orthopedic injuries, burns, and sciatica has been corroborated by a substantial and largely consistent body of evidence from clinical trials.

Conclusions

Owing to anti-inflammatory, anti-edematous, fibrinolytic, anti-infective, and analgesic effects, trypsin,chymotrypsin oral combination has emerged as a promising treatment to facilitate healing of traumatic injuries. It promotes speedier recovery and better resolution of inflammatory signs and symptoms due to tissue injury than several of the other existing enzyme preparations. It also demonstrates analgesic effects and reduces pain associated with healing. The efficacy and safety of trypsin,chymotrypsin in accidental injuries, surgical and orthopedic injuries, burns, and sciatica has been corroborated by a substantial and largely consistent body of evidence from clinical trials.

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